Victoria Louise Hand was a virtual recreation of the real-world person with the same name inside the Framework. Serving as a high-ranking Level 8 S.H.I.E.L.D. agent, she was well-known within the organization and had a reputation for brusqueness and strictness.
She was sent by S.H.I.E.L.D. to recruit Grant Ward, who had been convicted on first-degree arson charges. Although Ward believed his life was over, Hand convinced him to join by telling him that he had the potential to be a good man.
At the time when HYDRA revealed itself to the world in 2014, Victoria Hand and her long time friend and companion Jonathan Garrett were among those that resisted HYDRA and sought to rebuild S.H.I.E.L.D. in the name of liberty and freedom. However, she was killed by HYDRA soldiers under the orders of the Doctor.