Katya May, formerly known as Katya Belyakov, was a former virtual recreation of the real-world person of the same name inside the Framework. She had become the adopted daughter of Melinda May, who took her to be raised in the USA as a registered citizen. When the framework version of HYDRA, which had operated under the shadows within S.H.I.E.L.D. like in the real world, decided to frame her by causing a massacre into making people believe that Katya was responsible for the deaths of 279 people, she went on the run, afraid that her adopted mother would not understand when she aligned herself with HYDRA.
After siding with S.H.I.E.L.D. which had become a resistance to remove HYDRA out of power, Katya learned about what the Framework was when she met Jemma Simmons and Daisy Johnson, who came from the real world. She became a faithful companion and offered her assistance in anyway to help Jemma and Daisy find their lost friends. Eventually, she followed her friends and her adopted mother, whom she reunited, into the real world as a living Inhuman and developing the same ability as her original self. However, when she came out from the Quantum Portal Machine that connected between the real world and the Framework, she experienced memories of the real Katya who was killed by May. She remains loyal and helped Coulson and his team to defeat Aida.